| First Author | Utsuyama M | Year | 2001 |
| Journal | Mech Ageing Dev | Volume | 122 |
| Issue | 3 | Pages | 341-52 |
| PubMed ID | 11311321 | Mgi Jnum | J:67770 |
| Mgi Id | MGI:1931382 | Doi | 10.1016/s0047-6374(00)00249-9 |
| Citation | Utsuyama M, et al. (2001) Immunological restoration and anti-tumor effect by Japanese herbal medicine in aged mice. Mech Ageing Dev 122(3):341-52 |
| abstractText | We examined the effect of two Japanese herbal medicines (Kampo-Hozai) on immunological functions and anti-tumor activity in old mice. Hochu-ekki-to (TJ-41) was remarkably effective in the restoration of impaired immune functions of old mice, in terms of number of T cells and NK cells, and anti-SRBC antibody response, while it was not effective in enhancing immune functions of young mice. Juzen-taiho-to was also effective in increasing the number of T cells, remarkably, and NK cells, slightly, in the aged mice. While a significant increase was not observed in young mice. NK activity increased both in young and old mice with the treatment of TJ-48. A significant decrease was observed in metastatic pulmonary colonies of B16 melanoma cells both in young and old mice treated with Juzen-taiho-to for 16 weeks. These results suggested that some of Japanese herbal medicines were useful in restoration of impaired immune functions of old mice and could be recommended for human elderly. |
