| First Author | Watanabe Y | Year | 2010 |
| Journal | Biochem J | Volume | 432 |
| Issue | 1 | Pages | 47-55 |
| PubMed ID | 20812917 | Mgi Jnum | J:166870 |
| Mgi Id | MGI:4849906 | Doi | 10.1042/BJ20100847 |
| Citation | Watanabe Y, et al. (2010) Chondroitin sulfate N-acetylgalactosaminyltransferase-1 is required for normal cartilage development. Biochem J 432(1):47-55 |
| abstractText | CS (chondroitin sulfate) is a glycosaminoglycan species that is widely distributed in the extracellular matrix. To understand the physiological roles of enzymes involved in CS synthesis, we produced CSGalNAcT1 (CS N-acetylgalactosaminyltransferase 1)-null mice. CS production was reduced by approximately half in CSGalNAcT1-null mice, and the amount of short-chain CS was also reduced. Moreover, the cartilage of the null mice was significantly smaller than that of wild-type mice. Additionally, type-II collagen fibres in developing cartilage were abnormally aggregated and disarranged in the homozygous mutant mice. These results suggest that CSGalNAcT1 is required for normal CS production in developing cartilage. |
