| Primary Identifier | MGI:2387861 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Sod1 |
| Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The gene was disrupted by replacement of exon 5 and flanking intronic sequences with a neomycin resistance cassette via homologous recombination. The mutation deletes C-terminal amino acids 120-154 which constitute the structure and function of the active site channel. Absence of gene expression in homozygous mutant animals was confirmed by Northern blot analysis of heart tissue. |
