| Type | MGI:General | Description | in response to hypoxia (10% O2), adult homozygotes (4-6 months of age) display a significantly reduced ventilatory response showing an increase of only 261 +/- 202 ml/min/kg in minute ventilation (VE) relative to 1008 +/- 154 ml/min/kg in wild-type controls in response to further hypoxia (7.5% O2), homozygotes display a severe ventilatory depression with the VE reduced below prehypoxic levels by 606 +/- 209 ml/min/kg, unlike wild-type controls where no additional increase in ventilation is observed but the VE remains above normoxic levels |
