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Protein Coding Gene : Fos FBJ osteosarcoma oncogene

Primary Identifier  MGI:95574 Organism  mouse, laboratory
Chromosome  12 NCBI Gene Number  14281
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including positive regulation of osteoclast differentiation; response to muscle stretch; and skeletal muscle cell differentiation. Located in endoplasmic reticulum and nucleus. Part of transcription factor AP-1 complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and limb. Orthologous to human FOS (Fos proto-oncogene, AP-1 transcription factor subunit).
PHENOTYPE: Null mutants are growth-retarded, most dying perinatally. Survivors have osteopetrosis and abnormal tooth eruption, gametogenesis, hemopoiesis, behavior and photoreceptor apoptosis. Hippocampal-specific mutants have seizures and highly excitable neurons. [provided by MGI curators]
  • synonyms:
  • MGD-MRK-19548,
  • MGD-MRK-9866,
  • cFos,
  • D12Rfj1,
  • DNA segment, Chr 12, Russel F. Jacoby 1,
  • Fos,
  • FBJ osteosarcoma oncogene,
  • c-fos

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

1 Involved In Mutations

0 Strain

0 Transcripts

8 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

30 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

4 Driver For