Primary Identifier | MGI:3794053 | Allele Type | Transgenic |
Attribute String | Constitutively active, Inserted expressed sequence | Gene | Tg(MMTV-Akt1*T308D*S473D)7Mul |
Strain of Origin | FVB/N | Is Recombinase | false |
Is Wild Type | false |
molecularNote | This transgene contains a constitutively active mouse Akt1, in which critical residues (T308D/S473D) for activation of Akt1 are replaced by negatively charged amino acids, under the control of the mouse mammary tumor virus LTR. Mammary glands express significant levels of the transgene. |