Primary Identifier | MGI:5606283 | Allele Type | Spontaneous |
Gene | mt-Tk | Strain of Origin | C57BL/6 |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Mitochondria with a ChrM:7731G>A mutation in the mitochondrially encoded lysine tRNA were identified in P29 cells. Cybrids created in B82 cells lacking mitochondrial DNA and then transferred to TT2-F ES cells were introduced into 8-cell stage embryos of ICR mice. Cybrids were estimated to have 70% mutant DNA. |