| Primary Identifier | MGI:88229 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 12269 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to be involved in several processes, including negative regulation of complement activation, classical pathway; regulation of opsonization; and response to symbiotic bacterium. Predicted to act upstream of or within complement activation, classical pathway and innate immune response. Predicted to be located in extracellular region. Predicted to be active in extracellular space and plasma membrane. Is expressed in foregut-midgut junction; midgut; midgut loop; renal calyx; and renal pelvis. Human ortholog(s) of this gene implicated in COVID-19. Orthologous to human C4BPA (complement component 4 binding protein alpha). PHENOTYPE: Male mice exhibit normal fertility and spermatozoa morphology and function. Mice homozygous for the same allele exhibit increase IL6 serum levels in response to LPS injection. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
