| Primary Identifier | MGI:2385754 | Allele Type | Transgenic |
| Attribute String | Dominant negative, Inserted expressed sequence | Gene | Tg(Eno2-Casp1-C285G)1Yuan |
| Is Recombinase | false | Is Wild Type | false |
| description | This allele is representative of 5 different founders carrying the highest number of transgene integrations. These are founders 7506, 7512, 7516, 7538, and 7539. |
| molecularNote | The transgene is comprised of a dominant negative mutant Casp1 gene carrying a cysteine to glycine substitution at position 285 (C285G) fused to lacZ and the enolase 2 promoter. The enolase 2 promoter was used to direct expression of the transgene to cells of the nervous system. Transgenic animals were identified by PCR genotyping. X-gal staining of transgenic tissues detected transgene expression in the dorsal root ganglion. |
