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Protein Coding Gene : Sfpq splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)

Primary Identifier  MGI:1918764 Organism  mouse, laboratory
Chromosome  4 NCBI Gene Number  71514
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables chromatin binding activity and transcription cis-regulatory region binding activity. Involved in several processes, including dendritic transport of messenger ribonucleoprotein complex; negative regulation of DNA-templated transcription; and negative regulation of circadian rhythm. Acts upstream of or within DNA damage response; chromosome organization; and positive regulation of sister chromatid cohesion. Located in dendrite cytoplasm and paraspeckles. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; lung mesenchyme; sensory organ; and testis. Orthologous to human SFPQ (splicing factor proline and glutamine rich).
PHENOTYPE: Mice homozygous for a null allele die embryonically. Heterozygous gene trap mice show abnormality in entrainment of circadian rhythm. [provided by MGI curators]
  • synonyms:
  • REP1,
  • splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated),
  • RIKEN cDNA 5730453G22 gene,
  • D4Ertd314e,
  • DNA segment, Chr 4, ERATO Doi 314, expressed,
  • MGI:1915728,
  • expressed sequence AU021830,
  • RIKEN cDNA 2810416M14 gene,
  • RIKEN cDNA 1110004P21 gene,
  • 2810416M14Rik,
  • MGI:1925565,
  • MGI:1196226,
  • AU021830,
  • RIKEN cDNA 9030402K04 gene,
  • 1110004P21Rik,
  • PSF,
  • MGI:2140463,
  • 5730453G22Rik,
  • MGI:1917845,
  • Sfpq,
  • 9030402K04Rik

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