| Primary Identifier | MGI:2389548 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Cyp19a1 |
| Transmission | Germline | Strain of Origin | 129S/SvEv-Gpi1<c> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Sequence encompassing the proximal promoter and exons 1 and 2 was replaced by a neomycin selection inserted by homologous recombination. The deleted region included transcriptional and translational start sites and encoded amino acids essential for transmembrane topology. RT-PCR analysis of ovary and brain tissue indicated an absence of transcript in homozygous mutant mice. |
