| Primary Identifier | IPR005365 | Type | Family |
| Short Name | Npr3 |
| description | In budding yeasts, Npr3 forms a complex with NPR2. This complex heterodimer is responsible for inactivating TORC1, an evolutionarily conserved protein complex that controls cell size via nutritional input signals, specifically, in response to amino acid starvation []. In fission yeast, Nitrogen permease regulator 3-like protein (part of GATOR complex) is dispensable for TORC1 regulation under amino acid starvation and thus, responds to nitrogen starvation [].In humans, Npr3 like protein, NPRL3, is part of the GATOR1 complex that functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway []. |
