| First Author | Tian T | Year | 2023 |
| Journal | Front Cell Neurosci | Volume | 17 |
| Pages | 1114037 | PubMed ID | 36909282 |
| Mgi Jnum | J:335141 | Mgi Id | MGI:7445266 |
| Doi | 10.3389/fncel.2023.1114037 | Citation | Tian T, et al. (2023) Forebrain E-I balance controlled in cognition through coordinated inhibition and inhibitory transcriptome mechanism. Front Cell Neurosci 17:1114037 |
| abstractText | INTRODUCTION: Forebrain neural networks are vital for cognitive functioning, and their excitatory-inhibitory (E-I) balance is governed by neural homeostasis. However, the homeostatic control strategies and transcriptomic mechanisms that maintain forebrain E-I balance and optimal cognition remain unclear. METHODS: We used patch-clamp and RNA sequencing to investigate the patterns of neural network homeostasis with suppressing forebrain excitatory neural activity and spatial training. RESULTS: We found that inhibitory transmission and receptor transcription were reduced in tamoxifen-inducible Kir2.1 conditional knock-in mice. In contrast, spatial training increased inhibitory synaptic connections and the transcription of inhibitory receptors. DISCUSSION: Our study provides significant evidence that inhibitory systems play a critical role in the homeostatic control of the E-I balance in the forebrain during cognitive training and E-I rebalance, and we have provided insights into multiple gene candidates for cognition-related homeostasis in the forebrain. |
