| First Author | Saulep-Easton D | Year | 2016 |
| Journal | Leukemia | Volume | 30 |
| Issue | 1 | Pages | 163-72 |
| PubMed ID | 26139429 | Mgi Jnum | J:230609 |
| Mgi Id | MGI:5763351 | Doi | 10.1038/leu.2015.174 |
| Citation | Saulep-Easton D, et al. (2016) The BAFF receptor TACI controls IL-10 production by regulatory B cells and CLL B cells. Leukemia 30(1):163-72 |
| abstractText | Interleukin (IL)-10-producing B cells (B10 cells) have emerged as important regulatory elements with immunosuppressive roles. Chronic lymphocytic leukemia (CLL) B cells also secrete IL-10 and share features of B10 cells, suggesting a possible contribution of CLL B cells to immunosuppression in CLL patients. Factors controlling the emergence of B10 cells are not known. B-cell-activating factor of the tumor necrosis factor (TNF) family (BAFF) is critical for B-cell maturation and survival, and is implicated in the development and progression of CLL. We sought to investigate the role of BAFF in the emergence of IL-10-producing regulatory B cells in healthy donors and CLL patients. Here, we report that BAFF signaling promotes IL-10 production by CLL B cells in a mouse model of CLL and in CLL patients. Moreover, BAFF-mediated IL-10 production by normal and CLL B cells is mediated via its receptor transmembrane activator and cyclophilin ligand interactor. Our work uncovered a major targetable pathway important for the generation of regulatory B cells that is detrimental to immunity in CLL. |
