| Primary Identifier | MGI:1891384 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 83456 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables RNA helicase activity and piRNA binding activity. Involved in several processes, including male meiosis I; piRNA processing; and siRNA-mediated retrotransposon silencing by heterochromatin formation. Located in pi-body. Is expressed in heart and testis. Human ortholog(s) of this gene implicated in spermatogenic failure. Orthologous to human MOV10L1 (Mov10 like RNA helicase 1). PHENOTYPE: Mice homozygous for a targeted allele lacking the helicase domain exhibit male infertility due to meiotic arrest, apoptosis, and derepression of retrotransposons in male germ cells. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
