| First Author | Cherukuri S | Year | 2005 |
| Journal | Cell Metab | Volume | 2 |
| Issue | 5 | Pages | 309-19 |
| PubMed ID | 16271531 | Mgi Jnum | J:129671 |
| Mgi Id | MGI:3769962 | Doi | 10.1016/j.cmet.2005.10.003 |
| Citation | Cherukuri S, et al. (2005) Unexpected role of ceruloplasmin in intestinal iron absorption. Cell Metab 2(5):309-19 |
| abstractText | Ferroxidases are essential for normal iron homeostasis in most organisms. The paralogous vertebrate ferroxidases ceruloplasmin (Cp) and hephaestin (Heph) are considered to have nonidentical functions in iron transport: plasma Cp drives iron transport from tissue stores while intestinal Heph facilitates iron absorption from the intestinal lumen. To clarify the function of Cp, we acutely bled Cp-/- mice to stress iron homeostasis pathways. Red cell hemoglobin recovery was defective in stressed Cp-/- mice, consistent with low iron availability. Contrary to expectations, iron was freely released from spleen and liver stores in Cp-/- mice, but intestinal iron absorption was markedly impaired. Phlebotomy of wild-type mice caused a striking shift of Cp from the duodenal epithelium to the underlying lamina propria, suggesting a critical function of Cp in basolateral iron transport. Regulated relocalization of intestinal Cp may represent a fail-safe mechanism in which Cp shares with Heph responsibility for iron absorption under stress. |
