Primary Identifier | MGI:1921811 | Organism | mouse, laboratory |
Chromosome | 8 | NCBI Gene Number | 74561 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within cell fate determination; enteroendocrine cell differentiation; and negative regulation of epithelial cell differentiation. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; ear; and gut. Orthologous to human NKX6-3 (NK6 homeobox 3). PHENOTYPE: Mice homozygous for a knock-out allele exhibit a significantly decreased number of gastrin-producing (G) cells in the stomach antrum, hypogastrinemia, and increased stomach luminal pH, with a corresponding increase in antral somatostatin-producing (D) cells. [provided by MGI curators] |