| Primary Identifier | MGI:1916428 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 69178 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable D1 dopamine receptor binding activity; dynactin binding activity; and phosphatidylinositol phosphate binding activity. Predicted to be involved in several processes, including pinocytosis; regulation of signal transduction; and retrograde transport, endosome to Golgi. Predicted to act upstream of or within endocytosis and protein transport. Predicted to be located in several cellular components, including brush border; endosome; and macropinocytic cup. Predicted to be part of retromer complex. Predicted to be active in endosome. Is expressed in several structures, including alimentary system; brain; cranium; genitourinary system; and sensory organ. Orthologous to human SNX5 (sorting nexin 5). PHENOTYPE: Mice homozygous for a gene trap allele exhibit impaired alveolar epithelial differentiation of type I cells, respiratory failure and lethality during the perinatal and postnatal periods. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
