| Primary Identifier | MGI:97297 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 17999 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables several functions, including ionotropic glutamate receptor binding activity; proline-rich region binding activity; and protein phosphorylated amino acid binding activity. Involved in negative regulation of vascular endothelial growth factor receptor signaling pathway and regulation of dendrite morphogenesis. Acts upstream of or within several processes, including circulatory system development; negative regulation of transcription by RNA polymerase II; and protein monoubiquitination. Located in cytosol; dendritic spine; and membrane. Part of ubiquitin ligase complex. Is active in glutamatergic synapse and postsynaptic cytosol. Is expressed in several structures, including alimentary system; eye; genitourinary system; limb; and nervous system. Orthologous to human NEDD4 (NEDD4 E3 ubiquitin protein ligase). PHENOTYPE: Homozygous mutation of this gene results in neonatal lethality and heterozygous mice have decreased body weights. Mice homozygous for a knockout allele exhibit impaired neurite development. Mice homozygous for a gene trapped allele on a B6 congenic background exhibit male to female sex reversal and lethality through fetal development. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
