| First Author | Oishi Y | Year | 2017 |
| Journal | Cell Metab | Volume | 25 |
| Issue | 2 | Pages | 412-427 |
| PubMed ID | 28041958 | Mgi Jnum | J:251870 |
| Mgi Id | MGI:6107059 | Doi | 10.1016/j.cmet.2016.11.009 |
| Citation | Oishi Y, et al. (2017) SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism. Cell Metab 25(2):412-427 |
| abstractText | Macrophages play pivotal roles in both the induction and resolution phases of inflammatory processes. Macrophages have been shown to synthesize anti-inflammatory fatty acids in an LXR-dependent manner, but whether the production of these species contributes to the resolution phase of inflammatory responses has not been established. Here, we identify a biphasic program of gene expression that drives production of anti-inflammatory fatty acids 12-24 hr following TLR4 activation and contributes to downregulation of mRNAs encoding pro-inflammatory mediators. Unexpectedly, rather than requiring LXRs, this late program of anti-inflammatory fatty acid biosynthesis is dependent on SREBP1 and results in the uncoupling of NFkappaB binding from gene activation. In contrast to previously identified roles of SREBP1 in promoting production of IL1beta during the induction phase of inflammation, these studies provide evidence that SREBP1 also contributes to the resolution phase of TLR4-induced gene activation by reprogramming macrophage lipid metabolism. |
