| First Author | Udagawa J | Year | 2006 |
| Journal | Endocrinology | Volume | 147 |
| Issue | 2 | Pages | 647-58 |
| PubMed ID | 16282354 | Mgi Jnum | J:105139 |
| Mgi Id | MGI:3614217 | Doi | 10.1210/en.2005-0791 |
| Citation | Udagawa J, et al. (2006) The role of leptin in the development of the cerebral cortex in mouse embryos. Endocrinology 147(2):647-58 |
| abstractText | Leptin is detected in the sera, and leptin receptors are expressed in the cerebrum of mouse embryos, suggesting that leptin plays a role in cerebral development. Compared with the wild type, leptin-deficient (ob/ob) mice had fewer cells at embryonic day (E) 16 and E18 and had fewer 5-bromo-2'-deoxyuridine(+) cells at E14 and E16 in the neuroepithelium. Intracerebroventricular leptin injection in E14 ob/ob embryos increased the number of neuroepithelium cells at E16. In cultured neurosphere cells, leptin treatment increased Hes1 mRNA expression and maintained neural progenitors. Astrocyte differentiation was induced by low-dose (0.1 microg/ml) but not high-dose (1 microg/ml) leptin. High-dose leptin decreased Id mRNA and increased Ngn1 mRNA in neurosphere cells. The neuropeptide Y mRNA level in the cortical plate was lower in ob/ob than the wild type at E16 and E18. These results suggest that leptin maintains neural progenitors and is related to glial and neuronal development in embryos. |
