| First Author | Vincent PF | Year | 2015 |
| Journal | Elife | Volume | 4 |
| PubMed ID | 26568308 | Mgi Jnum | J:228056 |
| Mgi Id | MGI:5705164 | Doi | 10.7554/eLife.10988 |
| Citation | Vincent PF, et al. (2015) A synaptic F-actin network controls otoferlin-dependent exocytosis in auditory inner hair cells. Elife 4:e10988 |
| abstractText | We show that a cage-shaped F-actin network is essential for maintaining a tight spatial organization of Cav1.3 Ca(2+) channels at the synaptic ribbons of auditory inner hair cells. This F-actin network is also found to provide mechanosensitivity to the Cav1.3 channels when varying intracellular hydrostatic pressure. Furthermore, this F-actin mesh network attached to the synaptic ribbons directly influences the efficiency of otoferlin-dependent exocytosis and its sensitivity to intracellular hydrostatic pressure, independently of its action on the Cav1.3 channels. We propose a new mechanistic model for vesicle exocytosis in auditory hair cells where the rate of vesicle recruitment to the ribbons is directly controlled by a synaptic F-actin network and changes in intracellular hydrostatic pressure. |
