| Primary Identifier | MGI:2687035 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 330450 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables alcohol-forming very long-chain fatty acyl-CoA reductase activity. Predicted to be involved in long-chain fatty-acyl-CoA metabolic process. Predicted to act upstream of or within wax biosynthetic process. Located in peroxisome. Is expressed in alveolar sulcus; anterior naris; brain; ovary; and skin. Used to study alopecia and dry eye syndrome. Orthologous to human FAR2 (fatty acyl-CoA reductase 2). PHENOTYPE: Mice homozygous for a knock-out allele exhibit abnormal sebaceous gland differentiation and secretion leading to altered skin lipid content and primary cicatricial alopecia. Another null allele shows dry eyes with plugged meibomian gland orifices, corneal damage, and tear film instability. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
