| Primary Identifier | MGI:1277962 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 15574 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Involved in double-strand break repair via homologous recombination; embryo development; and regulation of protein phosphorylation. Acts upstream of or within DNA damage checkpoint signaling and response to UV. Predicted to be located in nucleus. Predicted to be part of checkpoint clamp complex. Predicted to be active in site of double-strand break. Is expressed in several structures, including brain; exocrine system; gonad; hemolymphoid system gland; and liver. Orthologous to human HUS1 (HUS1 checkpoint clamp component). PHENOTYPE: Homozygotes for a targeted null mutation exhibit defects in yolk sac vascularization, placental abnormalities, extensive apoptosis, and midgestational lethality. Mutant cells show increased chromosomal abnormalities. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
