| Primary Identifier | IPR039444 | Type | Domain |
| Short Name | SIR2-like |
| description | This entry represents a sirtuin-like domain domain found in FAM118A and FAM118B from vertebrates and bacterial NAD(+) hydrolase ThsA. ThsA is a component of bacterial antiphage defense system Thoeris and has robust NAD+ cleavage activity. It consists of a N-terminal NAD-binding domain (denoted as sirtuin-like or Macro) and C-terminal SLOG-like domain (). In some instances, such as in B. amyloliquefaciens, ThsA has an N-terminal transmembrane domain [2]. In ThsA, this domain binds and cleaves NAD+, required for antiphage activity [, ].FAM118A has been identified as a gene expressed in glioblastoma stem cells, but not expressed in neural stem cells []. Its function is unkown.Cajal bodies are specialized compartments in the nucleus that are involved in the biogenesis of small nuclear ribonucleoproteins (snRNPs). FAM118B is a component of Cajal bodies that plays an important role in Cajal body formation, snRNP biogenesis and cell viability []. |
