| Primary Identifier | MGI:106035 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 17345 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable ATP binding activity and DNA binding activity. Involved in regulation of chromatin organization. Acts upstream of or within several processes, including cholangiocyte proliferation; hepatocyte proliferation; and stem cell proliferation. Located in chromosome; cytoplasm; and nucleolus. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skin. Human ortholog(s) of this gene implicated in several diseases, including Crohn's disease; colorectal cancer; endocrine gland cancer (multiple); graft-versus-host disease; and human immunodeficiency virus infectious disease. Orthologous to human MKI67 (marker of proliferation Ki-67). PHENOTYPE: Mice carrying a reporter allele show expression in actively dividing cells. Mice homozygous for an endonuclease-mediated hypomorphic allele are resistant to chemical induction of intestinal tumorigenesis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
