| Primary Identifier | MGI:1914838 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 67588 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables erythropoietin receptor binding activity and interleukin-3 receptor binding activity. Acts upstream of or within several processes, including negative regulation of mitophagy; protein polyubiquitination; and regulation of hemopoiesis. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in endoplasmic reticulum tubular network. Is expressed in several structures, including central nervous system; dorsal root ganglion; male reproductive system; and urinary system. Human ortholog(s) of this gene implicated in congenital heart disease. Orthologous to human RNF41 (ring finger protein 41). PHENOTYPE: Mice homozygous for a transgenic gene disruption exhibit male infertility. In contrast, mice homozygous for a gene trapped allele showed no overt phenotypes but show an increase in activation of naive CD8+ T cells before TCR engagement. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
