| First Author | Ito K | Year | 1990 |
| Journal | Cell | Volume | 62 |
| Issue | 3 | Pages | 549-61 |
| PubMed ID | 2379238 | Mgi Jnum | J:23655 |
| Mgi Id | MGI:71530 | Doi | 10.1016/0092-8674(90)90019-b |
| Citation | Ito K, et al. (1990) Recognition of the product of a novel MHC TL region gene (27b) by a mouse gamma delta T cell receptor. Cell 62(3):549-61 |
| abstractText | The gamma delta T cell receptor (TCR) derived from the mouse KN6 T cell hybridoma recognizes an autologous determinant encoded by a broadly expressed gene mapping in the TL region of the major histocompatibility complex (MHC). We have cloned the gene and demonstrated that it is a novel class I gene (designated 27b) belonging to a hitherto undescribed TL region gene cluster in strain C57BL/6. The BALB/c allele of 27b, gene T17c, is defective because it lacks an appropriate splice acceptor site, which explains the lack of recognition of BALB/c stimulator cells by the KN6 cells. We propose that gamma delta TCR and nonclassical MHC and MHC-related class I molecules have coevolved to recognize a conserved set of endogenous and foreign determinants. |
