| First Author | Yanagawa S | Year | 2000 |
| Journal | J Virol | Volume | 74 |
| Issue | 20 | Pages | 9786-91 |
| PubMed ID | 11000255 | Mgi Jnum | J:64596 |
| Mgi Id | MGI:1889688 | Doi | 10.1128/jvi.74.20.9786-9791.2000 |
| Citation | Yanagawa S, et al. (2000) Identification of notch1 as a frequent target for provirus insertional mutagenesis in T-cell lymphomas induced by leukemogenic mutants of mouse mammary tumor virus. J Virol 74(20):9786-91 |
| abstractText | In contrast to wild-type mouse mammary tumor virus (MMTV), the MMTV mutants with specific deletions in the U3 region of their long terminal repeats cause T-cell lymphomas. In 30% of T-cell lymphomas arising in BALB/c mice infected with MLA-MMTV, a leukemogenic MMTV mutant, we have found that MMTV proviruses were integrated into a short region of the Notch1 genome, so that truncated Notch1 transcripts encoding the transmembrane and the cytoplasmic domains of Notch1 protein could be expressed. Thus, Notch1 is a major target of provirus insertional mutagenesis in these T-cell lymphomas. |
