| First Author | Sano H | Year | 1997 |
| Journal | Immunology | Volume | 92 |
| Issue | 1 | Pages | 118-22 |
| PubMed ID | 9370933 | Mgi Jnum | J:42629 |
| Mgi Id | MGI:1096054 | Doi | 10.1046/j.1365-2567.1997.00322.x |
| Citation | Sano H, et al. (1997) A nitric oxide-releasing reagent, S-nitroso-N-acetylpenicillamine, enhances the expression of superoxide dismutases mRNA in the murine macrophage cell line RAW264-7. Immunology 92(1):118-22 |
| abstractText | Murine interferon-gamma (IFN-gamma) stimulates the murine macrophage tumour cell line RAW264-7 to produce nitric oxide (NO). IFN-gamma induces expression of inducible NO synthase (iNOS), manganese superoxide dismutase (Mn-SOD) and copper zinc SOD (CuZn-SOD) in these cells. To investigate the mechanism of induction of SOD expression, we added S-nitroso-N-acetyl penicillamine (SNAP) to RAW264-7 cells. SNAP enhanced the expression of Mn-SOD and CuZn-SOD. These results suggest that when producing NO, RAW264-7 cells express SOD that might protect them from NO toxicity. |
