| First Author | Brunette RL | Year | 2012 |
| Journal | J Exp Med | Volume | 209 |
| Issue | 11 | Pages | 1969-83 |
| PubMed ID | 23045604 | Mgi Jnum | J:190914 |
| Mgi Id | MGI:5450754 | Doi | 10.1084/jem.20121960 |
| Citation | Brunette RL, et al. (2012) Extensive evolutionary and functional diversity among mammalian AIM2-like receptors. J Exp Med 209(11):1969-83 |
| abstractText | Innate immune detection of nucleic acids is important for initiation of antiviral responses. Detection of intracellular DNA activates STING-dependent type I interferons (IFNs) and the ASC-dependent inflammasome. Certain members of the AIM2-like receptor (ALR) gene family contribute to each of these pathways, but most ALRs remain uncharacterized. Here, we identify five novel murine ALRs and perform a phylogenetic analysis of mammalian ALRs, revealing a remarkable diversification of these receptors among mammals. We characterize the expression, localization, and functions of the murine and human ALRs and identify novel activators of STING-dependent IFNs and the ASC-dependent inflammasome. These findings validate ALRs as key activators of the antiviral response and provide an evolutionary and functional framework for understanding their roles in innate immunity. |
