| First Author | Chen ZY | Year | 2006 |
| Journal | Science | Volume | 314 |
| Issue | 5796 | Pages | 140-3 |
| PubMed ID | 17023662 | Mgi Jnum | J:113019 |
| Mgi Id | MGI:3664352 | Doi | 10.1126/science.1129663 |
| Citation | Chen ZY, et al. (2006) Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior. Science 314(5796):140-3 |
| abstractText | A common single-nucleotide polymorphism in the brain-derived neurotrophic factor (BDNF) gene, a methionine (Met) substitution for valine (Val) at codon 66 (Val66Met), is associated with alterations in brain anatomy and memory, but its relevance to clinical disorders is unclear. We generated a variant BDNF mouse (BDNF(Met/Met)) that reproduces the phenotypic hallmarks in humans with the variant allele. BDNF(Met) was expressed in brain at normal levels, but its secretion from neurons was defective. When placed in stressful settings, BDNF(Met/Met) mice exhibited increased anxiety-related behaviors that were not normalized by the antidepressant, fluoxetine. A variant BDNF may thus play a key role in genetic predispositions to anxiety and depressive disorders. |
