First Author | Yauch RL | Year | 1995 |
Journal | J Virol | Volume | 69 |
Issue | 11 | Pages | 7315-8 |
PubMed ID | 7474161 | Mgi Jnum | J:29244 |
Mgi Id | MGI:76775 | Doi | 10.1128/jvi.69.11.7315-7318.1995 |
Citation | Yauch RL, et al. (1995) Identification of a major T-cell epitope within VP3 amino acid residues 24 to 37 of Theiler's virus in demyelination-susceptible SJL/J mice. J Virol 69(11):7315-8 |
abstractText | Intracerebral inoculation of susceptible strains of mice with Theiler's murine encephalomyelitis virus (TMEV) results in a chronic, immunologically mediated demyelinating disease that shares many features with human multiple sclerosis. CD4+ T lymphocytes play a critical role in the pathogenesis of virus-induced demyelinating disease. We have identified a region within amino acid residues 24 to 37 of the VP3 capsid protein of TMEV (VP3(24-37)) that is recognized by T lymphocytes from the demyelination-susceptible SJL/J strain of mice. The T-cell response to VP3(24-37) represents a predominant Th-cell response against the virus from either TMEV-immunized or TMEV-infected SJL/J mice, and viral epitopes VP1(233-250), VP2(74-86), and VP3(24-37) account for most of the Th-cell response to TMEV. |