| First Author | Takagishi Y | Year | 1996 |
| Journal | Neurosci Lett | Volume | 215 |
| Issue | 3 | Pages | 169-72 |
| PubMed ID | 8899740 | Mgi Jnum | J:36532 |
| Mgi Id | MGI:83960 | Doi | 10.1016/0304-3940(96)12967-0 |
| Citation | Takagishi Y, et al. (1996) The dilute-lethal (dl) gene attacks a Ca2+ store in the dendritic spine of Purkinje cells in mice. Neurosci Lett 215(3):169-72 |
| abstractText | The absence of smooth endoplasmic reticulum (SER) in the dendritic spine of Purkinje cells was found in dilute- lethal (d(l)) mouse cerebella as detected by immunohistochemistry using anti-inositol 1,4,5- triphosphate receptor antibody and electron microscopy. Since SER in the spine has been suggested to play a crucial role for synaptic regulation as an intracellular Ca2+ store (for reviews, see [Miller, R.J., Frog. Neurobiol., 37 (1991) 255-285; Simpson, P.B., Challiss, R.A.J. and Nahorski, S.R., Trends Neurosci., 18 (1995) 299- 306]), a neurological defect, characterized by clonic convulsions with opisthotonus and ataxia, in the dilute- lethal mouse with homozygous trait may be attributable to the absence of SER in the dendritic spine of Purkinje cells. |
