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Protein Domain : Nucleolar protein Swm2

Primary Identifier  IPR031391 Type  Family
Short Name  Swm2
description  Swm2 (Synthetic With MUD-2-delta protein2) binds Tgs1, an enzyme responsible for 2,2,7-trimethylguanosine (TMG) capping of small nuclear (sn) RNAs implicated in pre-mRNA splicing [, , ]. Deletion of SWM2 impairs pre-mRNA splicing and ribosome biogenesis, exhibiting a similar phenotype to tgs1 mutant. Swm2 is required for trimethylation of spliceosomal snRNAs and the U3 snoRNA by Tgs1 [].

0 Child Features

0 Parent Features

0 Protein Domain Regions