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Protein Coding Gene : Fdxr ferredoxin reductase

Primary Identifier  MGI:104724 Organism  mouse, laboratory
Chromosome  11 NCBI Gene Number  14149
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Predicted to enable NADPH binding activity and NADPH-adrenodoxin reductase activity. Predicted to be involved in NADPH oxidation and steroid biosynthetic process. Predicted to act upstream of or within cholesterol metabolic process. Located in mitochondrial inner membrane. Orthologous to human FDXR (ferredoxin reductase).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit abnormal embryonic development and embryonic lethality likely due to iron overload. Heterozygotes exhibit premature death and are prone to spontaneous tumors and liver abnormalities, including steatosis, hepatitis, and hepatocellular carcinoma. [provided by MGI curators]
  • synonyms:
  • ferredoxin reductase,
  • MGD-MRK-27087,
  • Fdxr

Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

0 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

11 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For