| First Author | Mackay LK | Year | 2013 |
| Journal | Nat Immunol | Volume | 14 |
| Issue | 12 | Pages | 1294-301 |
| PubMed ID | 24162776 | Mgi Jnum | J:208724 |
| Mgi Id | MGI:5564868 | Doi | 10.1038/ni.2744 |
| Citation | Mackay LK, et al. (2013) The developmental pathway for CD103(+)CD8+ tissue-resident memory T cells of skin. Nat Immunol 14(12):1294-301 |
| abstractText | Tissue-resident memory T cells (T(RM) cells) provide superior protection against infection in extralymphoid tissues. Here we found that CD103(+)CD8(+) T(RM) cells developed in the skin from epithelium-infiltrating precursor cells that lacked expression of the effector-cell marker KLRG1. A combination of entry into the epithelium plus local signaling by interleukin 15 (IL-15) and transforming growth factor-beta (TGF-beta) was required for the formation of these long-lived memory cells. Notably, differentiation into T(RM) cells resulted in the progressive acquisition of a unique transcriptional profile that differed from that of circulating memory cells and other types of T cells that permanently reside in skin epithelium. We provide a comprehensive molecular framework for the local differentiation of a distinct peripheral population of memory cells that forms a first-line immunological defense system in barrier tissues. |
