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Publication : Poly(ADP-ribose) polymerase: a molecular nick-sensor.

First Author  de Murcia G Year  1994
Journal  Trends Biochem Sci Volume  19
Issue  4 Pages  172-6
PubMed ID  8016868 Mgi Jnum  J:53844
Mgi Id  MGI:1334829 Doi  10.1016/0968-0004(94)90280-1
Citation  de Murcia G, et al. (1994) Poly(ADP-ribose) polymerase: a molecular nick-sensor [published erratum appears in Trends Biochem Sci 1994 Jun;19(6):250]. Trends Biochem Sci 19(4):172-6
abstractText  Poly(ADP-ribose) polymerase (PARP) participates in the intricate network of systems developed by the eukaryotic cell to cope with the numerous environmental and endogenous genotoxic agents. Cloning of the PARP gene has allowed the development of genetic and molecular approaches to elucidate the structure and function of this abundant and highly conserved enzyme.
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