| Primary Identifier | MGI:1931053 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 57438 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables enzyme binding activity and ubiquitin binding activity. Involved in protein autoubiquitination. Acts upstream of or within negative regulation of T cell proliferation and regulation of tolerance induction. Located in cytosol; nucleus; and plasma membrane. Is expressed in brain; early conceptus; and telencephalon. Orthologous to human MARCHF7 (membrane associated ring-CH-type finger 7). PHENOTYPE: Homozygous null mice show premature neural degeneration and defective development of the corpus callosum. Both T cell proliferation and T cell-derived leukaemia inhibitory factor are increased. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
