First Author | Blasco MA | Year | 2003 |
Journal | Curr Opin Genet Dev | Volume | 13 |
Issue | 1 | Pages | 70-6 |
PubMed ID | 12573438 | Mgi Jnum | J:82092 |
Mgi Id | MGI:2450826 | Doi | 10.1016/s0959-437x(02)00011-4 |
Citation | Blasco MA (2003) Telomeres and cancer: a tale with many endings. Curr Opin Genet Dev 13(1):70-6 |
abstractText | Telomerase activity is necessary to maintain the integrity of telomeres, which in turn prevent chromosome ends from being processed and signaled as damaged DNA. That cancer cells rely on telomerase to maintain functional telomeres and to divide indefinitely has highlighted the potential for developing novel therapeutic approaches that target telomerase. |