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Protein Coding Gene : Pou4f1 POU domain, class 4, transcription factor 1

Primary Identifier  MGI:102525 Organism  mouse, laboratory
Chromosome  14 NCBI Gene Number  18996
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Enables several functions, including DNA binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and GTPase binding activity. Involved in several processes, including cellular response to estradiol stimulus; nervous system development; and regulation of gene expression. Acts upstream of or within several processes, including nervous system development; proprioception involved in equilibrioception; and suckling behavior. Located in cytoplasm; neuron projection; and nucleus. Part of RNA polymerase II transcription regulator complex and chromatin. Is expressed in several structures, including branchial arch mesenchyme; central nervous system; future brain; ganglia; and sensory organ. Orthologous to human POU4F1 (POU class 4 homeobox 1).
PHENOTYPE: Mice homozygous for disruptions in this gene die within the first day after birth and display various abnormalities in the brain and cranial nerves. [provided by MGI curators]
  • synonyms:
  • Brn3a,
  • POU domain, class 4, transcription factor 1,
  • MGD-MRK-1629,
  • RIKEN cDNA E130119J07 gene,
  • Pou4f1,
  • MGD-MRK-19369,
  • MGD-MRK-1630,
  • MGD-MRK-1625,
  • brain 3,
  • Brn-3,
  • Brn3a POU domain transcription factor,
  • Brn-3.0,
  • E130119J07Rik,
  • Brn3,
  • MGI:1925256

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

2 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

6 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

4 Driver For