| Primary Identifier | MGI:98953 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 22408 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables cytokine activity and protein domain specific binding activity. Involved in several processes, including central nervous system development; embryonic brain development; and negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway. Acts upstream of or within several processes, including nervous system development; positive regulation of hematopoietic stem cell proliferation; and regulation of protein metabolic process. Located in cell surface and extracellular region. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; embryo ectoderm; and genitourinary system. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 15. Orthologous to human WNT1 (Wnt family member 1). PHENOTYPE: In mild form, homozygotes have ataxia and hypertonia, with malformation of anterior cerebellum, deep midline fissure, and impaired fertility. In the severe form, there is virtually no midbrain and cerebellum and mutants die within hours of birth. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
