| First Author | Michel ML | Year | 2012 |
| Journal | Proc Natl Acad Sci U S A | Volume | 109 |
| Issue | 43 | Pages | 17549-54 |
| PubMed ID | 23047700 | Mgi Jnum | J:190365 |
| Mgi Id | MGI:5448756 | Doi | 10.1073/pnas.1204327109 |
| Citation | Michel ML, et al. (2012) Interleukin 7 (IL-7) selectively promotes mouse and human IL-17-producing gammadelta cells. Proc Natl Acad Sci U S A 109(43):17549-54 |
| abstractText | IL-17-producing CD27(-) gammadelta cells (gammadelta(27-) cells) are widely viewed as innate immune cells that make critical contributions to host protection and autoimmunity. However, factors that promote them over IFN-gamma-producing gammadelta(27+) cells are poorly elucidated. Moreover, although human IL-17-producing gammadelta cells are commonly implicated in inflammation, such cells themselves have proved difficult to isolate and characterize. Here, murine gammadelta(27-) T cells and thymocytes are shown to be rapidly and substantially expanded by IL-7 in vitro and in vivo. This selectivity owes in substantial part to the capacity of IL-7 to activate STAT3 in such cells. Additionally, IL-7 promotes strong responses of IL-17-producing gammadelta cells to TCR agonists, thus reemphasizing the cells' adaptive and innate potentials. Moreover, human IL-17-producing gammadelta cells are also substantially expanded by IL-7 plus TCR agonists. Hence, IL-7 has a conserved potential to preferentially regulate IL-17-producing gammadelta cells, with both biological and clinical implications. |
