| First Author | McLaren L | Year | 2000 |
| Journal | Mech Dev | Volume | 96 |
| Issue | 2 | Pages | 237-41 |
| PubMed ID | 10960791 | Mgi Jnum | J:64301 |
| Mgi Id | MGI:1889077 | Doi | 10.1016/s0925-4773(00)00388-9 |
| Citation | McLaren L, et al. (2000) Expression and genomic characterization of protein phosphatase inhibitor-1: a novel marker for mesothelium in the mouse. Mech Dev 96(2):237-41 |
| abstractText | Protein phosphatase inhibitor-1 (inhibitor-1 or I-1) is involved in signal transduction and is an endogenous inhibitor of protein phosphatase-1. The mouse I-1 protein sequence has been deduced from cDNA and is strongly homologous to the published rat sequence. A mouse genomic library was screened, and the I-1 gene was characterized and localized by fluorescent in situ hybridization (FISH) to chromosome 15F. Protein expression in a range of embryonic and adult tissue was analysed using confocal microscopy. Inhibitor-1 is expressed by: the coelomic epithelium; the epithelial bounding layer of cells of the kidney, lung, liver, heart, intestine and gonad; and the surface ectoderm. The blast cells of the kidney do not express I-1. We conclude that I-1 is a marker for mesothelium. |
