| First Author | Schneider EH | Year | 2014 |
| Journal | Behav Genet | Volume | 44 |
| Issue | 5 | Pages | 498-515 |
| PubMed ID | 24997773 | Mgi Jnum | J:329762 |
| Mgi Id | MGI:6871987 | Doi | 10.1007/s10519-014-9665-7 |
| Citation | Schneider EH, et al. (2014) Regulation of motor function and behavior by atypical chemokine receptor 1. Behav Genet 44(5):498-515 |
| abstractText | Atypical Chemokine Receptor 1 (ACKR1), previously known as Duffy Antigen Receptor for Chemokines, stands out among chemokine receptors for high selective expression on cerebellar Purkinje neurons. Although ACKR1 ligands activate Purkinje cells in vitro, evidence for ACKR1 regulation of brain function in vivo is lacking. Here we demonstrate that Ackr1 (-/-) mice have markedly impaired balance and ataxia on a rotating rod and increased tremor when injected with harmaline, which induces whole-body tremor by activating Purkinje cells. Ackr1 (-/-) mice also exhibited impaired exploratory behavior, increased anxiety-like behavior and frequent episodes of marked hypoactivity under low-stress conditions. Surprisingly, Ackr1 (+/-) had similar behavioral abnormalities, indicating pronounced haploinsufficiency. The behavioral phenotype of Ackr1 (-/-) mice was the opposite of mouse models of cerebellar degeneration, and the defects persisted when Ackr1 was deficient only on non-hematopoietic cells. Together, the results suggest that normal motor function and behavior may partly depend on negative regulation of Purkinje cell activity by Ackr1. |
