| First Author | Schneider K | Year | 2012 |
| Journal | EMBO Rep | Volume | 13 |
| Issue | 12 | Pages | 1138-44 |
| PubMed ID | 23079727 | Mgi Jnum | J:200473 |
| Mgi Id | MGI:5508702 | Doi | 10.1038/embor.2012.158 |
| Citation | Schneider K, et al. (2012) CAVIN-3 regulates circadian period length and PER:CRY protein abundance and interactions. EMBO Rep 13(12):1138-44 |
| abstractText | In mammals, transcriptional autorepression by Period (PER) and Cryptochrome (CRY) protein complexes is essential for the generation of circadian rhythms. We have identified CAVIN-3 as a new, cytoplasmic PER2-interacting protein influencing circadian clock properties. Thus, CAVIN-3 loss- and gain-of-function shortened and lengthened, respectively, the circadian period in fibroblasts and affected PER:CRY protein abundance and interaction. While depletion of protein kinase Cdelta (PKCdelta), a known partner of CAVIN-3, had little effect on circadian gene expression, CAVIN-3 required the PKCdelta-binding site to exert its effect on period length. This suggests the involvement of yet uncharacterized protein kinases. Finally, CAVIN-3 activity in circadian gene expression was independent of caveolae. |
