| First Author | Fast LD | Year | 1990 |
| Journal | J Immunol | Volume | 144 |
| Issue | 11 | Pages | 4177-82 |
| PubMed ID | 2111342 | Mgi Jnum | J:10517 |
| Mgi Id | MGI:58967 | Doi | 10.4049/jimmunol.144.11.4177 |
| Citation | Fast LD (1990) Identification of a single non-H-2 gene regulating graft-versus-host disease response. J Immunol 144(11):4177-82 |
| abstractText | Non-MHC loci have been shown to play an important role in the development and regulation of graft-vs-host disease (GVHD). In the murine model of GVHD under study, injection of C57BL/6 spleen cells into unirradiated (C57BL/6 x DBA/2)F1 hybrid recipient mice results in an acute form of GVHD characterized by CTL, suppressor cells, and runting. In contrast, injection of DBA/2 spleen cells into the same recipients results in a chronic form of GVHD that is characterized by a lack of CTL and hyperproduction of Ig and autoantibodies. After preliminary studies with the use of congenic mice showed that non-MHC loci were controlling GVHD responses in this model, genetic analysis of GVHD response of BXD recombinant inbred strains and (B10.D2 x DBA/2) X DBA/2 BC mice identified a single locus, Gvh, on chromosome 7 that controls whether acute or chronic GVHD results from injection of parental lymphocytes into unirradiated (C57BL/6 x DBA/2)F1 recipient mice. |
