| First Author | Plumb M | Year | 1997 |
| Journal | Int J Radiat Biol | Volume | 72 |
| Issue | 1 | Pages | 1-9 |
| PubMed ID | 9246189 | Mgi Jnum | J:42229 |
| Mgi Id | MGI:1095367 | Doi | 10.1080/095530097143482 |
| Citation | Plumb M, et al. (1997) Ongoing Y-chromosome instability defines sub-clonal variants in radiation-induced leukaemias in the mouse. Int J Radiat Biol 72(1):1-9 |
| abstractText | Forty primary leukaemias that arose in vivo as a consequence of 3 Gy X-irradiation of inbred mouse strains were analysed for S'-chromosome aberrations by conventional cyto-genetics and fluorescent in situ hybridization (FISH). Compared with control mice which were X-irradiated but which exhibited no overt signs of leukaemia, the loss and gain of Y-chromosomes in leukaemic,spleen cells defined subclonal variants in the radiation-induced haempoietic malignancies that arose in CBA/H, DBA/2 and (C57BL/6 x DBA/2)F1 mice. This Y- chromosome instability was significantly higher than that observed in spleen cells of age-matched (or older) irradiated control mice that had not developed overt leukaemia. The detection of Y-chromosome aberrations is considered in the context of the high numbers of potential gene regulatory sequences in the murine Y-chromosome and the potential for the insertional activation of cellular genes during multi-stage radiation leukaemogenesis. |
