| Primary Identifier | IPR042735 | Type | Domain |
| Short Name | FCHo1_F-BAR |
| description | F-BAR domain only protein 1 (FCHo1) belongs to the F-BAR family, whose members have been implicated in cell membrane processes such as membrane invagination, tubulation and endocytosis []. FCHo1 functions in an early step of clathrin-mediated endocytosis. It has a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits []. It contains an N-terminal F-BAR domain and a C-terminal domain of unknown function named SAFF which is also present in FCHo2 and endophilin interacting protein 1. This entry represents the F-BAR domain, which forms banana-shaped dimers with a positively-charged concave surface that binds to negatively-charged lipid membranes. It can induce membrane deformation in the form of long tubules [, ]. |
