| Primary Identifier | IPR022114 | Type | Family |
| Short Name | DMRT1-like |
| description | This family is found in eukaryotes, and is typically between 61 and 73 amino acids in length. They are suggested to be transcription factor proteins.In Xenopus laevis, doublesex- and mab-3-related transcription factor 1a (dmrt1-a) is a transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and germ cell proliferation. It acts both as a transcription repressor and activator [, ]. However, the other family member in Xenopus laevis, doublesex- and mab-3-related transcription factor DM-W (dm-w), is a transcription factor that plays a key role in female sex determination and primary ovary development. It acts as a sex-determining protein by antagonizing the transcriptional activity of male-determination protein dmrt1-a, acting as a dominant-negative type protein [, ]. |
